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Abstract

Oxygen has been considered a potentially life-saving drug in life-threatening situations for decades. It is crucial in the
perioperative period, where it is used daily by millions of surgical patients of all ages. Iatrogenic hyperoxia is as damaging
as hypoxia, especially in young children and neonates. There is a growing awareness about this problem. Significant
discoveries about the effect of oxygen on oxidative stress and cellular damage due to oxygen intoxication must contribute
to developing hyperoxia monitoring, oxygen dosing guidelines, and revising the safe limits of hyperoxia. The consequences
of hyperoxia can be irreversible damage to the vulnerable organs (lungs and brain), which mainly affects developing
organisms.

Keywords: hyperoxia, oxidative stress, high oxygen concentration, neonatal anesthesia

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58 DOI: 10.5937/Galmed2308054S