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Abstract
Diabetic foot (DF) is a complication resulting from long-term, inadequately treated diabetes mellitus (DM). The foundation
of diabetic foot lies in the presence of chronic complications on the foot associated with DM. Significant challenges in
addressing the complex issue of DF pose a challenge to better understanding and optimizing DF treatment. Diabetes
leads to a reduction in blood flow in arterial blood vessels, resulting in decreased perfusion to all tissues. This leads to
reduced vitality and functionality of all tissues, particularly noticeable in the feet, which are the most distal parts of the
body exposed to load. Changes in DF manifest with diverse clinical presentations, ranging from local to systemic, and vary
in extent from subtle and barely noticeable to gangrene. Diagnosis is generally straightforward and based on medical
history, clinical presentation, laboratory testing, and radiography. Treatment can be preventive, primarily through patient
education about possible diabetes complications and lifestyle changes. Treatment for existing foot changes is based on foot
offloading, medications, and surgical intervention in cases of significant complications, deformities, necrosis, and infection.
Surgical treatment can be preventive and reconstructive. Preventive surgical treatment involves establishing better
anatomical relationships to evenly distribute pressure on soft tissues. Reconstructive surgical treatment encompasses
all procedures and surgical techniques aimed at preserving anatomical integrity, function, and reducing disability. A
multidisciplinary approach to addressing the complex issue of DF yields the best results and significantly reduces mortality
and the need for radical surgical interventions such as below-knee and above-knee amputations. Timely intervention
with appropriate medication and surgical therapy, along with continuous monitoring, is essential to avoid additional
complications, shorten treatment duration, and reduce the extent and radical nature of surgical procedures.
Keywords: diabetes mellitus, diabetic foot, surgical treatment, ulcerations, Charcot neuroarthropathy
Literatura 11. Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE,
Bennett DL, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019 Jun
13;5(1):42.
1. Monteiro-Soares M, Boyko EJ, Jeffcoate W, Mills JL, Russell D, Morbach S, 12. Galiero R, Caturano A, Vetrano E, Beccia D, Brin C, Alfano M, et al.
et al. Diabetic foot ulcer classifications: A critical review. Diabetes Metab Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms
Res Rev. 2020 Mar;36 Suppl 1:e3272.
and Diagnostic Options. Int J Mol Sci. 2023 Feb 10;24(4):3554.
2. Jirkovská A. Péce o pacienty se syndromem diabetické nohy podle 13. Pop-Busui R, Ang L, Boulton AJM, Feldman EL, Marcus RL, Mizokami-
mezinárodního konsenzu [Care of patients with the diabetic foot Stout K, et al. Diagnosis and Treatment of Painful Diabetic Peripheral
syndrome based on an international consensus]. Cas Lek Cesk. 2001 Neuropathy. Arlington (VA): American Diabetes Association; 2022 Feb.
Apr 26;140(8):230-3.
14. Ueda M, Makoto O, Sakai A. Use of a Skin-Covering Pocket as a Local
3. Choi T, Osuagwu UL, Tran C, Bulsari K, Simmons D. Impact of Flap and Negative Pressure Wound Therapy with Instillation and Dwell
multidisciplinary care of diabetic foot infections for inpatients at Time/Negative Pressure Wound Therapy for the Treatment of Diabetic
Campbelltown Hospital. BMC Health Serv Res. 2023 Oct 19;23(1):1126. Foot Ulcer with Calcaneal Osteomyelitis: A Case Report. J Am Podiatr
4. Li T, Li Z, Huang L, Tang J, Ding Z, Zeng Z, et al. Cigarette Smoking and Med Assoc. 2023 Sep-Oct;113(5):21-061.
Peripheral Vascular Disease are Associated with Increasing Risk of 15. Ivanova Y, Gramatiuk S, Kryvoruchko I, Tymchenko M, Goltsev K,
ESKAPE Pathogen Infection in Diabetic Foot Ulcers. Diabetes Metab Sargsyan K. Investigating the joint application of negative pressure
Syndr Obes. 2022 Oct 26;15:3271-83.
wound treatment and tissue therapy for chronic wounds in patients
5. Vadiveloo T, Jeffcoate W, Donnan PT, Colhoun HC, McGurnaghan with diabetes. J Med Life. 2023 Jul;16(7):1098-104.
S, Wild S, et al. Scottish Diabetes Research Network Epidemiology 16. Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, et al.
Group. Amputation-free survival in 17,353 people at high risk for foot Diabetic peripheral neuropathy: advances in diagnosis and strategies
ulceration in diabetes: a national observational study. Diabetologia. for screening and early intervention. Lancet Diabetes Endocrinol. 2019
2018 Dec;61(12):2590-7. Dec;7(12):938-48.
6. Frykberg RG, Zgonis T, Armstrong DG, Driver VR, Giurini JM, Kravitz 17. Braffett BH, Gubitosi-Klug RA, Albers JW, Feldman EL, Martin CL,
SR, et al. American College of Foot and Ankle Surgeons. Diabetic foot White NH, et al. DCCT/EDIC Research Group. Risk Factors for Diabetic
disorders. A clinical practice guideline (2006 revision). J Foot Ankle Surg. Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in
2006 Sep-Oct;45(5 Suppl):S1-66. the Diabetes Control and Complications Trial/Epidemiology of Diabetes
7. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Interventions and Complications (DCCT/EDIC) Study. Diabetes. 2020
et al. IDF Diabetes Atlas: Global, regional and country-level diabetes May;69(5):1000-10.
prevalence estimates for 2021 and projections for 2045. Diabetes Res 18. Ziegler D, Papanas N, Schnell O, Nguyen BDT, Nguyen KT,
Clin Pract. 2022 Jan;183:109119.
Kulkantrakorn K, et al. Current concepts in the management of diabetic
8. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. polyneuropathy. J Diabetes Investig. 2021 Apr;12(4):464-75.
IDF Diabetes Atlas Committee. Global and regional diabetes prevalence 19. Kerr M, Barron E, Chadwick P, Evans T, Kong WM, Rayman G, et al. The
estimates for 2019 and projections for 2030 and 2045: Results from the cost of diabetic foot ulcers and amputations to the National Health
International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Service in England. Diabet Med. 2019 Aug;36(8):995-1002.
Res Clin Pract. 2019 Nov;157:107843.
20. Bus SA, Armstrong DG, Gooday C, Jarl G, Caravaggi C, Viswanathan
9. Zhang Y, Lazzarini PA, McPhail SM, van Netten JJ, Armstrong DG, Pacella V, et al. International Working Group on the Diabetic Foot (IWGDF).
RE. Global Disability Burdens of Diabetes-Related Lower-Extremity Guidelines on offloading foot ulcers in persons with diabetes (IWGDF
Complications in 1990 and 2016. Diabetes Care. 2020 May;43(5):964-74. 2019 update). Diabetes Metab Res Rev. 2020 Mar;36 Suppl 1:e3274.
10. Pop-Busui R, Ang L, Boulton AJM, Feldman EL, Marcus RL, Mizokami- 21. Wu B, Wan X, Ma J. Cost-effectiveness of prevention and management
Stout K, et al. Diagnosis and Treatment of Painful Diabetic Peripheral of diabetic foot ulcer and amputation in a health resource-limited
Neuropathy. Arlington (VA): American Diabetes Association; 2022 Feb.
setting. J Diabetes. 2018 Apr;10(4):320-7.
REVIJALNI RADOVI Galenika Medical Journal, 2023; 2(8):35-42. 41

